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  1. Home
  2. Marfan Syndrome

Marfan Syndrome

The three most common structural building blocks that constitute the ‘connective tissues’ are the proteins Collagen,  Fibrillin,  and Elastin. They all have important functions in maintaining elasticity and strength of these tissues. In Marfan syndrome (MFS), there is not enough Fibrillin in the connective tissues.

The biology of this is more complex than it just being about the physical amount of Fibrillin present; it is also about how Fibrillin interacts with another protein called Transforming Growth Factor – Beta and how this influences normal biochemical processes in the connective tissue. When these interactions go wrong the tissues can become weak and fragile. Fibrillin is found mainly in bones, the aorta (main artery) and the eyes. Hence, these are the parts of the body most prone to complications in MFS. The clinical features of MFS vary considerably from person to person, with many people having only mild features. Everyone with MFS is born with the condition, but it may not be obvious before the teenage years (during the growth spurt). To add to the complexity some of the complications may not arise for many years, if indeed they arise at all. Every case has to be managed at an individual level.

If you click HERE you will be taken to the The Marfan Foundation website where there further information regarding Marfan syndrome.

(Review date August 2019)

If you would like the clinical references for the information used in this article, please contact us via the Information Standards Enquiry from.

Marfan Syndrome: Joints, Bones and the Marfanoid habitus

Marfan Syndrome: Joints, Bones and the Marfanoid habitus

A more detailed look at the musculo skeletal aspects of Marfan syndrome Read more

Published: 25th July, 2019

Updated: 13th September, 2019

Author: Hannah Ensor

Related topics:
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Marfan Syndrome: an overview of clinical features

Marfan Syndrome: an overview of clinical features

An overview of the clinical features of, and diagnostic test for Marfan syndrome, Read more

Published: 25th July, 2019

Updated: 12th September, 2019

Author: Hannah Ensor

Related topics:
  • Marfan
  • diagnositic criteria
  • test
  • MarfanPage
  • marfan syndrome
  • Types of hypermobility syndromes
  • Marfan Syndrome
Marfan Syndrome: The Eyes

Marfan Syndrome: The Eyes

How Marfan syndrome can affect the eyes, and what the available treatment and management options are. Read more

Published: 25th July, 2019

Updated: 12th September, 2019

Author: Hannah Ensor

Related topics:
  • Marfan
  • eye
  • lens
  • MarfanPage
  • marfan syndrome
  • Types of hypermobility syndromes
  • Marfan Syndrome
Marfan Syndrome: The Lungs

Marfan Syndrome: The Lungs

An overview of how Marfan syndrome can affect the lungs. Read more

Published: 25th July, 2019

Updated: 29th August, 2019

Author: Hannah Ensor

Related topics:
  • Marfan
  • lungs
  • MarfanPage
  • marfan syndrome
  • Marfan Syndrome
Marfan syndrome: Gene and Inheritance

Marfan syndrome: Gene and Inheritance

An outline of the genetics of marfan syndrome Read more

Published: 25th July, 2019

Updated: 29th August, 2019

Author: Hannah Ensor

Related topics:
  • MarfanPage
  • Types of hypermobility syndromes
  • Marfan Syndrome
Marfan Syndrome: Heart and Blood vessels

Marfan Syndrome: Heart and Blood vessels

A more detailed look at the problems that can arise in Marfan syndrome relative to the heart and blood vessels, and their management. Read more

Published: 25th July, 2019

Updated: 29th August, 2019

Author: Hannah Ensor

Related topics:
  • aortic aneurism
  • Marfan
  • treatment
  • heart
  • blood
  • MarfanPage
  • marfan syndrome
  • aneurism
  • Types of hypermobility syndromes
  • Marfan Syndrome

Marfan Syndrome: Nerves

Information on how the Dura (lining the brain and spinal cord) can be affected by Marfan syndrome Read more

Published: 25th July, 2019

Author: Hannah Ensor

Related topics:
  • Types of hypermobility syndromes
  • Marfan Syndrome
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Showing 10 of 7

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Tag cloud

2017conference child EDS EDSPage hEDS HMS HSD hypermobile ehlers danlos hypermobility hypermobility spectrum disorder Kent Model kid Marfan marfan syndrome MarfanPage Trustee

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