i found that it took around a fortnight for me to notice any obvious effect on my pains and insomnia, and as i have a neurological sleep disorder (i get blocked from entering REM so get bounced back to being wide awake when i try and sleep, and when i do get into REM i sleep walk, talk and have terrors that all wake me up) the ami wasnt a miracle fix but it does mean that when i do get into REM sleep i tend to have a large improvement in my sleep quality and feel less like death the next morning.
i take mine between 7 and 9 pm at night now, although i used to take it earlier when i started it as it seemed to take longer to kick in- i assume the levels needed time to build up in my system.
i also find that my fibro pains are far less once my dose kicks in, although i'm not sure if the slight drowsyness caused by the ami is simply distracting me. but this also means i sleep easier cos it doesnt hurt so much to lay in bed
i like my ami! its one of my meds that i really cant be without and if i forget to take it i proper notice it by around midnight!!